Histopathology of Chronic Compression

[A's Mommy]

My husband did some searching for me and came up with an article from a medical textbook that described the histopathology of chronic nerve compression. This was in regards to CARPAL TUNNEL SYNDROME, which as many of you know, the PNE doctors often compare PNE with CPS. I will try to scan in the diagram tomorrow, but wanted to post a bit about it.

Histopathology ---> Blood-nerve barrier breakdown ---> Endoneurial edema ---> Connective tissue thickening ---> Localized fiber demyelination ---> Diffuse fiber demyelination ---> Axonal degeneration

Symptoms ---> Intermittent paresthesia and/or aching ---> Constant paresthesia and/or weakness ---> Numbness and atrophy

Sensory testing ---> Positive provocative maneuvers ---> Abnormal thresholds ---> Abnormal two-point discrimination

Hope this helps. It helped me understand a little bit about how the scar tissue possibly developed around my nerve from the compression of my child's growing body inside me, not moving due to my uterine abnormality.

A's Mommy

[Violet M]

Interesting.

Dr. Antolak is one of the few PNE docs I know of who does threshold and sensory testing and I had some very abnormal results from those tests. For instance when he put a warm (not hot) object on my skin it burned for several minutes after he removed it. Can't remember if he did a two point discrimination test but he did pinprick tests and I felt the pinprick in an entirely different area than where it really was.

[pianogal]

very interesting. will read again when more alert. yes, i know, I'm supposed to be taking two days off from PNE research. See how good I am at staying away from it? lol (I suck). I just can't stop.

nonetheless, very interesting.

my antolak sensory test showed less than regular sensation rectally, more than usual sensation in my inner thighs and I guess labially... need to find that paper.